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{07} {35} {36} Both allopurinol and the uricosuric antigout agents are effective in patients whose 24-hour renal excretion of uric acid is 800 mg (4. Keep Allopurinol out of the reach of children and away from pets. The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. A 63-year-old man receiving allopurinol for gout developed progressive uremia, proteinuria, edema, and purpura after beginning quinidine therapy. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. {06} {35} {36} However, the uricosuric agents are less toxic than allopurinol and should be considered for use when appropriate {37}.

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